Emerging role of RNA interference in immune cells engineering and its therapeutic synergism in immunotherapy

نویسندگان

چکیده

RNAi effectors (e.g. siRNA, shRNA and miRNA) can trigger the silencing of specific genes causing alteration genomic functions becoming a new therapeutic area for treatment infectious diseases, neurodegenerative disorders cancer. In cancer treatment, showed potential immunomodulatory actions by down-regulating immuno-suppressive proteins, such as PD-1 CTLA-4, which restrict immune cell function present challenges in immunotherapy. Therefore, compared with extracellular targeting antibodies, RNAi-mediated cell-intrinsic disruption inhibitory pathways cells could promote an increased anti-tumour response. Along non-viral vectors, DNA-based strategies might be more promising method immunomodulation to silence multiple T than checkpoint blockade antibodies. Thus, this review, we discuss diverse implementation strategies, recent viral mediated synergism immunotherapy that augments immunity. Finally, provide current progress clinical pipeline.

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ژورنال

عنوان ژورنال: British Journal of Pharmacology

سال: 2021

ISSN: ['0007-1188', '1476-5381']

DOI: https://doi.org/10.1111/bph.15414